History: This mass was resected from the tail of the pancreas of a 28 year old woman. What is the best diagnosis?
Answer :Solid pseudopapillary neoplasm.
Comment: This type of tumor is malignant but not nearly as aggressive as pancreatic adenocarcinoma. It tends to present in young women but any age and both genders are affected. The hyaline globules are typical and nuclear grooves can be prominent. Nuclear beta catenin staining is the rule, as is expression of BCL10.
This case was provided Dr. Elizabeth Montgomery, Professor of Pathology and Vice Chair of Anatomic Pathology at the University of Miami, and Editor-In-Chief of the Pathology Survival Guides at Innovative Science Press. Check out her GI and Soft Tissue books as well as our new titles at: