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Case of the Week

Horrible treatment (radiation) associated epithelial changes in duodenal mucosa. The p53 can be ignored, probably reflecting upregulation rather thana mutational event. The same can be seen in the stomach.


Hutchings DA, Salimian KJ, Waters KM, Birkness-Gartman JE, Voltaggio L, Assarzadegan N, Huang J, Lin MT, Singhi AD, Montgomery EA. Aberrant p53 Expression in Gastric Biopsies and Resection Specimens Following Neoadjuvant Chemoradiation: A Diagnostic Pitfall. Int J Surg Pathol. 2023 Dec;31(8):1458-1465. PMID: 36843539.



Case by Dr. Elizabeth Montgomery, Clinical Professor, Vice Chair of Faculty Development & Mentoring, Director of Surgical Pathology Fellowship Training Program, Co-Director, Pathology Reference Services, and Editor-In-Chief at Innovative Science Press.


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