History: This image is from a fine needle aspiration biopsy of a lymph node in a patient with lymphadenopathy, joint symptoms, and elevated ACE. What is your diagnosis? Answer: Well-formed granuloma characteristic of sarcoidosis. Comment: This air-dried smear demonstrates well-formed granulomata. The histiocyte nuclei are elongated with a shape reminiscent of a footprint. Their arrangement in granulomata have been described as being like a “dance step diagram”. Case pro

It is rare in the tubular gastrointestinal tract, but globular amyloid is associated with light chain restriction. There is no neoplasm here, but the patient should be investigated for a plasma cell disorder. Hemmer PR, Topazian MD, Gertz MA, Abraham SC. Globular amyloid deposits isolated to the small bowel: a rare association with AL amyloidosis. Am J Surg Pathol. 2007 Jan;31(1):141-5. PMID: 17197930. Case by Dr. Elizabeth Montgomery, Clinical Professor, Vice Chair of Facult