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Case of the Week

It's a little pitfall for when we get too carried away with immunohistochemistry when we knew the answer on H&E. This is a gastric leiomyoma near the esophageal junction. Those little Cajal cells are just growing along with the lesion bothering no one except those who love immunohistochemical stains a tad too much!


1. Taşkın OÇ, Armutlu A, Adsay V, Aslan F, Kapran Y. Clinicopathologic and immunohistochemical characteristics of upper gastrointestinal leiomyomas harboring interstitial cells of Cajal: A potential mimicker of gastrointestinal stromal tumor. Ann Diagn Pathol. 2020 Apr;45:151476.


2. Deshpande A, Nelson D, Corless CL, Deshpande V, O'Brien MJ. Leiomyoma of the gastrointestinal tract with interstitial cells of Cajal: a mimic of gastrointestinal stromal tumor. Am J Surg Pathol. 2014 Jan;38(1):72-7



Case provided by Dr. Elizabeth Montgomery, Clinical Professor, Vice Chair of Faculty Development & Mentoring, Director of Surgical Pathology Fellowship Training Program, Co-Director, Pathology Reference Services, and Editor-In-Chief at Innovative Science Press.


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