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Prostate Biopsy: Your Diagnosis?

Answer: Cribriform clear cell hyperplasia. This is a gland with cribriform architecture composed of cells with small nuclei and inconspicuous nucleoli. Note clusters of basal cells at the periphery of the duct/gland. This should not be confused with cribriform cancer (either intraductal carcinoma or invasive cribriform carcinoma). The key is to recognize the lack of cytologic atypia.