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Case of the Week

History: This mass was resected from the tail of the pancreas of a 28 year old woman. What is the best diagnosis?

Diagnosis: Solid pseudopapillary neoplasm.

Comment: This type of tumor is malignant but not nearly as aggressive as pancreatic adenocarcinoma. It tends to present in young women, but any age and both genders are affected. The hyaline globules are typical, and nuclear grooves can be prominent. Nuclear beta catenin staining is the rule, as is expression of BCL10.

PMID: 24418850

This case was provided by Dr. Elizabeth Montgomery, Professor of Pathology and Vice Chair of Anatomic Pathology at the University of Miami, and the Editor-in-Chief of Innovative Science Press. You can check out her GI and Soft Tissue volumes as well as our other titles: Liver, Endocrine, Dermpath, Prostate, Lymph Node and more at:


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