Chronic Eosinophilic Leukemia
A. Peripheral blood shows an abnormal eosinophil with vacuoles, abnormal granulation, and some with >2 lobes. These findings, out of context, are atypical, but in a case with significant eosinophilia, they would be more suggestive of a myeloid neoplasm. B. Aspirate smear in CEL with markedly increased eosinophils and precursors. C. Core in CEL with increased eosinophils. Also, note the dysplastic appearing megakaryocyte.
This is figure 5-12 that Dr. Montgomery selected from the newly released Survival Guide to Bone Marrow Pathology by Drs. O'Malley and Cherry.
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