Images show a case of adenosquamous carcinoma of the prostate. Adenosquamous carcinoma and squamous cell carcinoma of the prostate are rare and can be secondary to previous therapy (androgen deprivation or radiation) or de novo. When there is prostate adenocarcinoma adjacent to a malignant squamous component, the tumor is termed adenosquamous carcinoma. Approximately 20% of prostate cancers with squamous differentiation also have a sarcomatoid component. The adenocarcinoma component consists of high grade prostatic acinar adenocarcinoma, and the squamous component consists of moderately differentiated keratinizing squamous cell carcinoma.
This case was provided by Drs. Jonathan Epstein, and Andres Matoso at the John Hopkins Hospital. The Survival Guide to Prostate Pathology which they recently wrote is published by Innovative Science Press. You can order your copy at: